Nursing in the United Kingdom has a long history. The current form of nursing is often considered as beginning with Florence Nightingale who pioneered modern nursing. Nightingale initiated formal schools of nursing in the United Kingdom in the late 19th and early 20th centuries. The role and perception of nursing has dramatically changed from that of a handmaiden to the doctor to professionals in their own right. There are over 500,000 nurses in the United Kingdom and they work in a variety of settings, such as hospitals, health centres, nursing homes, hospices, communities, and academia, with most working for the National Health Service (NHS). Nurses work across all demographics and requirements of the public: adults, children, mental health, and learning disability. Nurses work in a range of specialties from the broad areas of medicine, surgery, theatres, and investigative sciences such as imaging. Nurses also work in large areas of sub-specialities such as respiratory, diabetes, neurology, infectious diseases, liver, research, cardiac, and stoma. Nurses often work in multi-disciplinary teams but increasingly are found working independently.

To practise, all nurses and nursing associates in the United Kingdom must be registered with the Nursing and Midwifery Council (NMC).